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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN4
All Species:
34.85
Human Site:
Y148
Identified Species:
85.19
UniProt:
O14493
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14493
NP_001296.1
209
22077
Y148
H
N
I
I
Q
D
F
Y
N
P
L
V
A
S
G
Chimpanzee
Pan troglodytes
XP_523276
220
23303
Y148
H
A
I
I
R
D
F
Y
N
P
L
V
A
E
A
Rhesus Macaque
Macaca mulatta
XP_001112477
209
22011
Y148
H
N
I
I
Q
D
F
Y
N
P
L
V
A
S
G
Dog
Lupus familis
XP_546920
210
22073
Y148
N
N
I
I
R
D
F
Y
N
P
L
V
V
S
G
Cat
Felis silvestris
Mouse
Mus musculus
O35054
210
22320
Y148
H
N
V
I
R
D
F
Y
N
P
M
V
A
S
G
Rat
Rattus norvegicus
Q63400
219
23296
Y147
N
T
I
I
R
D
F
Y
N
P
L
V
P
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510834
206
21755
Y145
N
N
I
I
R
D
F
Y
N
P
T
V
S
Q
G
Chicken
Gallus gallus
NP_989533
214
23072
Y147
N
T
I
I
R
D
F
Y
N
P
L
V
I
D
A
Frog
Xenopus laevis
NP_001089583
209
22234
Y148
N
N
I
I
R
D
F
Y
N
P
L
V
V
E
A
Zebra Danio
Brachydanio rerio
Q9YH91
208
22187
Y148
N
S
V
I
K
D
F
Y
N
P
T
L
S
D
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
60
99
90.9
N.A.
83.3
64.3
N.A.
84.6
67.2
75.1
65.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
80
99.5
95.7
N.A.
94.2
80.3
N.A.
93.7
84.5
90.9
82.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
73.3
100
80
N.A.
80
60
N.A.
66.6
60
66.6
40
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
80
100
93.3
N.A.
100
73.3
N.A.
86.6
73.3
80
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
0
0
0
40
0
50
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
100
0
0
0
0
0
0
0
20
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
30
0
% E
% Phe:
0
0
0
0
0
0
100
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
50
% G
% His:
40
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
80
100
0
0
0
0
0
0
0
0
10
0
0
% I
% Lys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
70
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
60
60
0
0
0
0
0
0
100
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
100
0
0
10
0
0
% P
% Gln:
0
0
0
0
20
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
70
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
10
0
0
0
0
0
0
0
0
0
0
20
40
0
% S
% Thr:
0
20
0
0
0
0
0
0
0
0
20
0
0
0
0
% T
% Val:
0
0
20
0
0
0
0
0
0
0
0
90
20
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _